For those of you who haven't seen it, Tara Parker-Pope write a nice article on obesity in the latest issue of NY Times Magazine (1). She discusses research showing that the body "resists" fat loss attempts, making it difficult to lose fat and maintain fat loss once obesity is established.
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Wednesday, 4 January 2012
Monday, 2 January 2012
High-Fat Diets, Obesity and Brain Damage
Many of you have probably heard the news this week:
High-fat diet may damage the brain
Eating a high-fat diet may rapidly injure brain cells
High fat diet injures the brain
Brain injury from high-fat foods
Your brain cells are exploding with every bite of butter! Just kidding. The study in question is titled "Obesity is Associated with Hypothalamic Injury in Rodents and Humans", by Dr. Josh Thaler and colleagues, with my mentor Dr. Mike Schwartz as senior author (1). We collaborated with the labs of Drs. Tamas Horvath and Matthias Tschop. I'm fourth author on the paper, so let me explain what we found and why it's important.
The Questions
Among the many questions that interest obesity researchers, two stand out:
The Findings
Read more »
High-fat diet may damage the brain
Eating a high-fat diet may rapidly injure brain cells
High fat diet injures the brain
Brain injury from high-fat foods
Your brain cells are exploding with every bite of butter! Just kidding. The study in question is titled "Obesity is Associated with Hypothalamic Injury in Rodents and Humans", by Dr. Josh Thaler and colleagues, with my mentor Dr. Mike Schwartz as senior author (1). We collaborated with the labs of Drs. Tamas Horvath and Matthias Tschop. I'm fourth author on the paper, so let me explain what we found and why it's important.
The Questions
Among the many questions that interest obesity researchers, two stand out:
- What causes obesity?
- Once obesity is established, why is it so difficult to treat?
The Findings
Read more »
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HCE user experience: The anabolic range may be better measured in seconds than repetitions
It is not uncommon for those who do weight training to see no gains over long periods of time for certain weight training exercises (e.g., overhead press), even while they experience gains in other types of exercise (e.g., regular squats).
HealthCorrelator for Excel (HCE) and its main outputs, coefficients of association and graphs (), have been helping some creative users identify the reasons why they see no gains, and break out of the stagnation periods.
It may be a good idea to measure the number of seconds of effort per set; in addition to other variables such as numbers of sets and repetitions, and the amount of weight lifted. In some cases, an inverted J curve, full or partial (just the left side of it), shows up suggesting that the number of seconds of effort in a particular type of weight training exercise is a better predictor of muscle gain than the number of repetitions used.
The inverted J curve is similar to the one discussed in a previous post on HCE used for weight training improvement, where the supercompensation phenomenon is also discussed ().
Repetitions in the 6-12 range are generally believed to lead to peak anabolic response, and this is generally true for weight training exercises conducted in good form and to failure. It is also generally believed that muscular effort should be maintained for 20 to 120 seconds for peak anabolic response.
The problem is that in certain cases not even 12 repetitions lead to at least 20 seconds of effort. This is usually the case when the repetitions are performed very quickly. There are a couple of good reasons why this may happen: the person has above-average muscular power, or the range of motion used is limited.
What is muscular power, and why would someone want to limit the range of motion used in a weight training exercise?
Muscular power is different from muscular strength, and is normally distributed (bell curve) across the population, like most human traints (). Muscular power is related to the speed with which an individual can move a certain amount of weight. Muscular strength is related to the amount of weight moved. Frequently people who perform amazing feats of strength, like Dennis Rogers (), have above-average muscular power.
As for limiting the range of motion used in a weight training exercise, one of the advantages of doing so is that it reduces the risk of injury, as a wise commenter pointed out here some time ago (). It also has the advantage of increasing the number of variations of an exercise that can be used at different points in time; which is desirable, as variation is critical for sustained supercompensation ().
The picture below is from a YouTube video clip showing champion natural bodybuilder Doug Miller performing 27 repetitions of the deadlift with 405 lbs (). Doug is one of the co-authors of the book Biology for Bodybuilders, which has been reviewed here ().
The point of showing the video clip above is that the range of repetitions used would be perceived as quite high by many bodybuilders, but is nevertheless the one leading to a peak anabolic response for Doug. If you pay careful attention to the video, you will notice that Doug completes the 27 repetitions in 45 seconds, well within the anabolic range. If he had completed only 12 repetitions, at about the same pace, he would have done that a few seconds before hitting the 20-second mark.
Doug completes those 27 repetitions relatively quickly, because he has above-average muscular power, in addition to having above-average muscular strength.
HealthCorrelator for Excel (HCE) and its main outputs, coefficients of association and graphs (), have been helping some creative users identify the reasons why they see no gains, and break out of the stagnation periods.
It may be a good idea to measure the number of seconds of effort per set; in addition to other variables such as numbers of sets and repetitions, and the amount of weight lifted. In some cases, an inverted J curve, full or partial (just the left side of it), shows up suggesting that the number of seconds of effort in a particular type of weight training exercise is a better predictor of muscle gain than the number of repetitions used.
The inverted J curve is similar to the one discussed in a previous post on HCE used for weight training improvement, where the supercompensation phenomenon is also discussed ().
Repetitions in the 6-12 range are generally believed to lead to peak anabolic response, and this is generally true for weight training exercises conducted in good form and to failure. It is also generally believed that muscular effort should be maintained for 20 to 120 seconds for peak anabolic response.
The problem is that in certain cases not even 12 repetitions lead to at least 20 seconds of effort. This is usually the case when the repetitions are performed very quickly. There are a couple of good reasons why this may happen: the person has above-average muscular power, or the range of motion used is limited.
What is muscular power, and why would someone want to limit the range of motion used in a weight training exercise?
Muscular power is different from muscular strength, and is normally distributed (bell curve) across the population, like most human traints (). Muscular power is related to the speed with which an individual can move a certain amount of weight. Muscular strength is related to the amount of weight moved. Frequently people who perform amazing feats of strength, like Dennis Rogers (), have above-average muscular power.
As for limiting the range of motion used in a weight training exercise, one of the advantages of doing so is that it reduces the risk of injury, as a wise commenter pointed out here some time ago (). It also has the advantage of increasing the number of variations of an exercise that can be used at different points in time; which is desirable, as variation is critical for sustained supercompensation ().
The picture below is from a YouTube video clip showing champion natural bodybuilder Doug Miller performing 27 repetitions of the deadlift with 405 lbs (). Doug is one of the co-authors of the book Biology for Bodybuilders, which has been reviewed here ().
The point of showing the video clip above is that the range of repetitions used would be perceived as quite high by many bodybuilders, but is nevertheless the one leading to a peak anabolic response for Doug. If you pay careful attention to the video, you will notice that Doug completes the 27 repetitions in 45 seconds, well within the anabolic range. If he had completed only 12 repetitions, at about the same pace, he would have done that a few seconds before hitting the 20-second mark.
Doug completes those 27 repetitions relatively quickly, because he has above-average muscular power, in addition to having above-average muscular strength.
Sponsored by:
Sunday, 1 January 2012
Junk Free January
Last year, Matt Lentzner organized a project called Gluten Free January, in which 546 people from around the world gave up gluten for one month. The results were striking: a surprisingly large proportion of participants lost weight, experienced improved energy, better digestion and other benefits (1, 2). This January, Lentzner organized a similar project called Junk Free January. Participants can choose between four different diet styles:
If you've been waiting for an excuse to improve your diet, why not join Junk Free January?
- Gluten free
- Seed oil free (soybean, sunflower, corn oil, etc.)
- Sugar free
- Gluten, seed oil and sugar free
If you've been waiting for an excuse to improve your diet, why not join Junk Free January?
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Monday, 26 December 2011
Ground meat treats: Zucchini and onion meatloaf
A cousin of the meatball (), the meatloaf is a traditional German dish. The recipe below is for a meal that feeds 4-8 people. The ground beef used has little fat, and thus a relatively low omega-6 content. Most of the fat comes from the 1 lb of ground grass-fed lamb in the recipe, which has a higher omega-3 to omega-6 ratio than the regular (i.e., non-grass-fed) ground beef. The egg acts as a binder. Leave the potato out if you want to decrease the carbohydrate content; it does not add much (nutrient numbers are provided at the end of the post).
- Prepare some dry seasoning powder by mixing salt, parsley flakes, garlic powder, chili powder, and a small amount of cayenne pepper.
- Grate one zucchini squash and one peeled potato. Cut half an onion into small pieces of similar size.
- Mix 2 lb of very lean ground beef (96/4) with 1 lb of ground grass-fed lamb.
- Add the dry seasoning, zucchini, potato, onion and a whole egg to the ground meat mix.
- Vigorously mix by hand until you get a homogeneous look.
- Place the mix into a buttered casserole dish with the shape of a loaf.
- Preheat the oven to 375 degrees Fahrenheit.
- Bake the meatloaf for about 1 hour and a half.
It is a good idea to place the casserole dish within a tray, as in the photo above. The meatloaf will give off some of its juices as it bakes, which may overflow from the casserole dish and make a mess in your oven. Below is a slice of meatloaf served with a side of vegetables. The green spots in the meatloaf are the baked zucchini squash pieces.
A thick slice like the one on the photo above will have about 52 g of protein, 15 g of fat, and 6 g of carbohydrates (mostly from the potato). That'll be about 1/5 of the whole meatloaf; the slice will weigh a little less then 1/2 lb (approximately 200 g). The fat will be primairly saturated and monounsaturated (both healthy), with a good balance of omega-3 and omega-6 fats. The slice of meatloaf will also be a good source of vitamins B12 and B6, niacin, zinc, selenium, and phosphorus.
- Prepare some dry seasoning powder by mixing salt, parsley flakes, garlic powder, chili powder, and a small amount of cayenne pepper.
- Grate one zucchini squash and one peeled potato. Cut half an onion into small pieces of similar size.
- Mix 2 lb of very lean ground beef (96/4) with 1 lb of ground grass-fed lamb.
- Add the dry seasoning, zucchini, potato, onion and a whole egg to the ground meat mix.
- Vigorously mix by hand until you get a homogeneous look.
- Place the mix into a buttered casserole dish with the shape of a loaf.
- Preheat the oven to 375 degrees Fahrenheit.
- Bake the meatloaf for about 1 hour and a half.
It is a good idea to place the casserole dish within a tray, as in the photo above. The meatloaf will give off some of its juices as it bakes, which may overflow from the casserole dish and make a mess in your oven. Below is a slice of meatloaf served with a side of vegetables. The green spots in the meatloaf are the baked zucchini squash pieces.
A thick slice like the one on the photo above will have about 52 g of protein, 15 g of fat, and 6 g of carbohydrates (mostly from the potato). That'll be about 1/5 of the whole meatloaf; the slice will weigh a little less then 1/2 lb (approximately 200 g). The fat will be primairly saturated and monounsaturated (both healthy), with a good balance of omega-3 and omega-6 fats. The slice of meatloaf will also be a good source of vitamins B12 and B6, niacin, zinc, selenium, and phosphorus.
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Monday, 19 December 2011
Protein powders before fasted weight training? Here is a more natural and cheaper alternative
The idea that protein powders should be consumed prior to weight training has been around for a while, and is very popular among bodybuilders. Something like 10 grams or so of branched-chain amino acids (BCAAs) is frequently recommended. More recently, with the increase in popularity of intermittent fasting, it has been strongly recommended prior to “fasted weight training”. The quotation marks here are because, obviously, if you are consuming anything that contains calories prior to weight training, the weight training is NOT being done in a fasted state.
Most of the evidence available suggests that intermittent fasting is generally healthy. In fact, being able to fast for 16 hours or more, particularly without craving sweet foods, is actually a sign of a healthy glucose metabolism; which may complicate a cause-and-effect analysis between intermittent fasting and general health. The opposite, craving sweet foods every few hours, is generally a bad sign.
One key aspect of intermittent fasting that needs to be highlighted is that it is also arguably a form of liberation ().
Now, doing weight training in the fasted state may or may not lead to muscle loss. It probably doesn’t, even after a 24-hour fast, for those who fast and replenish their glycogen stores on a regular basis ().
However, weight training in a fasted state frequently induces an exaggerated epinephrine-norepinephrine (i.e., adrenaline-noradrenaline) response, likely due to depletion of liver glycogen beyond a certain threshold (the threshold varies for different people). The same is true for prolonged or particularly intense weight training sessions, even if they are not done in the fasted state. The body wants to crank up consumption of fat and ketones, so that liver glycogen is spared to ensure that it can provide the brain with its glucose needs.
Exaggerated epinephrine-norepinephrine responses tend to cause a few sensations that are not very pleasant. One of the first noticeable ones is orthostatic hypotension; i.e., feeling dizzy when going from a sitting to a standing position. Other related feelings are light-headedness, and a “pins and needles” sensation in the limbs (typically the arms and hands). Many believe that they are having a heart attack whey they have this “pins and needles” sensation, which can progress to a stage that makes it impossible to continue exercising.
Breaking the fast prior to weight training with dietary fat or carbohydrates is problematic, because those nutrients tend to blunt the dramatic rise in growth hormone that is typically experienced in response to weight training (). This is not good because the growth hormone response is probably one of the main reasons why weight training can be so healthy ().
Dietary protein, however, does not seem to significantly blunt the growth hormone response to weight training; even though it doesn't seem to increase it either (). Dietary protein seems to also suppress the exaggerated epinephrine-norepinephrine response to fasted weight training. And, on top of all that, it appears to suppress muscle loss, which may well be due to a moderate increase in circulating insulin ().
So everything points at the possibility that the ingestion of some protein, without carbohydrates or fat, is a good idea prior to fasted weight training. Not too much protein though, because insulin beyond a certain threshold is also likely to suppress the growth hormone response.
Does the protein have to be in the form of a protein powder? No.
Supplements are made from food, and this is true of protein powders as well. If you hard-boil a couple of large eggs, and eat only the whites prior to weight training, you will be getting about 8-10 grams of one of the highest quality protein "supplements" you can possibly get. Included are BCAAs. You will get a few extra nutrients with that too, but virtually no fat or carbohydrates.
(Source: Ecopaper.com)
Most of the evidence available suggests that intermittent fasting is generally healthy. In fact, being able to fast for 16 hours or more, particularly without craving sweet foods, is actually a sign of a healthy glucose metabolism; which may complicate a cause-and-effect analysis between intermittent fasting and general health. The opposite, craving sweet foods every few hours, is generally a bad sign.
One key aspect of intermittent fasting that needs to be highlighted is that it is also arguably a form of liberation ().
Now, doing weight training in the fasted state may or may not lead to muscle loss. It probably doesn’t, even after a 24-hour fast, for those who fast and replenish their glycogen stores on a regular basis ().
However, weight training in a fasted state frequently induces an exaggerated epinephrine-norepinephrine (i.e., adrenaline-noradrenaline) response, likely due to depletion of liver glycogen beyond a certain threshold (the threshold varies for different people). The same is true for prolonged or particularly intense weight training sessions, even if they are not done in the fasted state. The body wants to crank up consumption of fat and ketones, so that liver glycogen is spared to ensure that it can provide the brain with its glucose needs.
Exaggerated epinephrine-norepinephrine responses tend to cause a few sensations that are not very pleasant. One of the first noticeable ones is orthostatic hypotension; i.e., feeling dizzy when going from a sitting to a standing position. Other related feelings are light-headedness, and a “pins and needles” sensation in the limbs (typically the arms and hands). Many believe that they are having a heart attack whey they have this “pins and needles” sensation, which can progress to a stage that makes it impossible to continue exercising.
Breaking the fast prior to weight training with dietary fat or carbohydrates is problematic, because those nutrients tend to blunt the dramatic rise in growth hormone that is typically experienced in response to weight training (). This is not good because the growth hormone response is probably one of the main reasons why weight training can be so healthy ().
Dietary protein, however, does not seem to significantly blunt the growth hormone response to weight training; even though it doesn't seem to increase it either (). Dietary protein seems to also suppress the exaggerated epinephrine-norepinephrine response to fasted weight training. And, on top of all that, it appears to suppress muscle loss, which may well be due to a moderate increase in circulating insulin ().
So everything points at the possibility that the ingestion of some protein, without carbohydrates or fat, is a good idea prior to fasted weight training. Not too much protein though, because insulin beyond a certain threshold is also likely to suppress the growth hormone response.
Does the protein have to be in the form of a protein powder? No.
Supplements are made from food, and this is true of protein powders as well. If you hard-boil a couple of large eggs, and eat only the whites prior to weight training, you will be getting about 8-10 grams of one of the highest quality protein "supplements" you can possibly get. Included are BCAAs. You will get a few extra nutrients with that too, but virtually no fat or carbohydrates.
Sponsored by:
Wednesday, 14 December 2011
A Sign of the Times
Every now and then, I venture out to go shopping at mainstream chain clothing stores. Although I find it onerous, there are certain things I can't get at thrift stores. For example, I can never find nice jeans.
The last time I set foot in these stores was about two years ago. It was tough to find pants my size at that time-- many stores simply didn't sell pants with a 30 inch waist. This year, it was even harder, since some of the stores that formerly carried 30W pants no longer did. I managed to find my usual 30W 30L size in two stores, but I had a bizarre experience in both cases. I put them on, and they were falling off my waist. Since my waist size hasn't changed in two years, and my old 30W 30L pants of the same brand still fit the same as they did when I bought them two years ago, I have to conclude that both stores have changed their definition of "30 inches". My new size is 28W 30L, which is tough to find these days.
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The last time I set foot in these stores was about two years ago. It was tough to find pants my size at that time-- many stores simply didn't sell pants with a 30 inch waist. This year, it was even harder, since some of the stores that formerly carried 30W pants no longer did. I managed to find my usual 30W 30L size in two stores, but I had a bizarre experience in both cases. I put them on, and they were falling off my waist. Since my waist size hasn't changed in two years, and my old 30W 30L pants of the same brand still fit the same as they did when I bought them two years ago, I have to conclude that both stores have changed their definition of "30 inches". My new size is 28W 30L, which is tough to find these days.
Read more »
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