Your Brain on Potato Chips

Or, more accurately, a rat's brain on potato chips.  Last week, PLoS One published a very interesting paper by Dr. Tobias Hoch and colleagues on what happens in a rat's brain when it is exposed to a highly palatable/rewarding food (1).  Rats, like humans, overconsume highly palatable foods even when they're sated on less palatable foods (2), and feeding rats a variety of palatable human junk foods is one of the most effective ways to fatten them (3).  Since the brain directs all behaviors, food consumption is an expression of brain activity patterns.  So what is the brain activity pattern that leads to the overconsumption of a highly palatable and rewarding food?

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Thai Peanut Noodles with Chicken

I have a few favorite dishes that I like to eat out at restaurants and figured, why not try to recreate them at home?  It may seem intimidating to make something you typically only order, but it's really satisfying to have at home, not to mention healthier, since you can control the ingredients.

Case in point here is Thai Peanut Noodles with Chicken.  I like this dish because it's colorful, full of veggies, like snap peas, radishes, red pepper and bok choy (chinese cabbage), and so flavorful.  I added in grilled chicken breast for extra protein.  Using a prepared rotisserie chicken is also good here, but then you're getting the dark (fattier) meat.

I steamed the snap peas for about two minutes, but tossed in the chopped radish, red pepper and bok choy in raw.  Doesn't get easier than that. 

I cheated a litte on the peanut sauce because I have some that I really like from the bottle (but it's not the healthiest so I use just a small amount), then add in natural peanut butter, chile sauce, lime, and sesame seeds. 

I used whole wheat spaghetti cooked according to package instructions.

Then assembled the whole thing.  I like this dish cold, but you can eat it warm too. 

What is your favorite restaurant dish to create at home?

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Salt Sugar Fat

I'd just like to put in a quick word for a book that will be released tomorrow, titled Salt Sugar Fat: How the Food Giants Hooked Us, by Pulitzer prize-winning author Michael Moss.  This is along the same lines as Dr. David Kessler's book The End of Overeating, which explains how the food industry uses food reward, palatability, and food cues to maximize sales-- and as an unintended side effect, maximize our waistlines.   Judging by Moss's recent article in New York Times Magazine, which I highly recommend reading, the book will be excellent.  I've pre-ordered it.

Could the low testosterone problem be a mirage?

Low testosterone (a.k.a. “low T”) is caused by worn out glands no longer able to secrete enough T, right? At least this seems to be the most prevalent theory today, a theory that reminds me a lot of the “tired pancreas” theory () of diabetes. I should note that this low T problem, as it is currently presented, is one that affects almost exclusively men, particularly middle-aged men, not women. This is so even though T plays an important role in women’s health.

There are many studies that show associations between T levels and all kinds of diseases in men. But here is a problem with hormones: often several hormones vary together and in a highly correlated fashion. If you rely on statistics to reach conclusions, you must use techniques that allow you to rule out confounders; otherwise you may easily reach wrong conclusions. Examples are multivariate techniques that are sensitive to Simpson’s paradox and nonlinear algorithms; both of which are employed, by the way, by modern software tools such as WarpPLS (). Unfortunately, these are rarely, if ever, used in health-related studies.

Many low T cases may actually be caused by something other than tired T-secretion glands, perhaps a hormone (or set of hormones) that suppress T production; a T “antagonist”. What would be a good candidate? The figure below shows two graphs. It is from a study by Starks and colleagues, published in the Journal of the International Society of Sports Nutrition in 2008 (). The study itself is not directly related to the main point that this post tries to make, but the figure is.



Look at the two graphs carefully. The one on the left is of blood cortisol levels. The one on the right is of blood testosterone levels. Ignore the variation within each graph. Just compare the two graphs and you will see one interesting thing – cortisol and testosterone levels are inversely related. This is a general pattern in connection with stress-induced cortisol elevations, repeating itself over and over again, whether the source of stress is mental (e.g., negative thoughts) or physical (e.g., intense exercise).

And the relationship between cortisol and testosterone is strong. Roughly speaking, an increase in cortisol levels, from about 20 to 40 μg/dl, appears to bring testosterone levels down from about 8 to 5 ηg/ml. A level of 8 ηg/ml (the same as 800 ηg/dl) is what is normally found in young men living in urban environments. A level of 5 ηg/ml is what is normally found in older men living in urban environments.

So, testosterone levels are practically brought down to almost half of what they were before by that variation in cortisol.

Chronic stress can easily bring your cortisol levels up to 40 μg/dl and keep them there. More serious pathological conditions, such as Cushing’s disease, can lead to sustained cortisol levels that are twice as high. There are many other things that can lead to chronically elevated cortisol levels. For instance, sustained calorie restriction raises cortisol levels, with a corresponding reduction in testosterone levels. As the authors of a study () of markers of semistarvation in healthy lean men note, grimly:

“…testosterone (T) approached castrate levels …”

The study highlights a few important phenomena that occur under stress conditions: (a) cortisol levels go up, and testosterone levels go down, in a highly correlated fashion (as mentioned earlier); and (b) it is very difficult to suppress cortisol levels without addressing the source of the stress. Even with testosterone administration, cortisol levels tend to be elevated.

Isn't possible that cortisol levels go up because testosterone levels go down - reverse causality? Possible, but unlikely. Evidence that testosterone administration may reduce cortisol levels, when it is found, tends to be rather weak or inconclusive. A good example is a study by Rubinow and colleagues (). Not only were their findings based on bivariate (or unadjusted) correlations, but also on a chance probability threshold that is twice the level usually employed in statistical analyses; the level usually employed is 5 percent.

Let us now briefly shift our attention to dieting. Dieting is the main source of calorie restriction in modern urban societies; an unnatural one, I should say, because it involves going hungry in the presence of food. Different people have different responses to dieting. Some responses are more extreme, others more mild. One main factor is how much body fat you want to lose (weight loss, as a main target, is a mistake); another is how low you expect body fat to get. Many men dream about six-pack abs, which usually require single-digit body fat percentages.

The type of transformation involving going from obese to lean is not “cost-free”, as your body doesn’t know that you are dieting. The body “sees” starvation, and responds accordingly.

Your body is a little bit like a computer. It does exactly what you “tell” it to do, but often not what you want it to do. In other words, it responds in relatively predictable ways to various diet and lifestyle changes, but not in the way that most of us want. This is what I call compensatory adaptation at work (). Our body often doesn’t respond in the way we expect either, because we don’t actually know how it adapts; this is especially true for long-term adaptations.

What initially feels like a burst of energy soon turns into something a bit more unpleasant. At first the unpleasantness takes the form of psychological phenomena, which were probably the “cheapest” for our bodies to employ in our evolutionary past. Feeling irritated is not as “expensive” a response as feeling physically weak, seriously distracted, nauseated etc. if you live in an environment where you don’t have the option of going to the grocery store to find fuel, and where there are many beings around that can easily kill you.

Soon the responses take the form of more nasty body sensations. Nearly all of those who go from obese to lean will experience some form of nasty response over time. The responses may be amplified by nutrient deficiencies. Obesity would have probably only been rarely, if ever, experienced by our Paleolithic ancestors. They would have never gotten obese in the first place. Going from obese to lean is as much a Neolithic novelty as becoming obese in the first place, although much less common.

And it seems that those who have a tendency toward mental disorders (e.g., generalized anxiety, manic-depression), even if at a subclinical level under non-dieting conditions, are the ones that suffer the most when calorie restriction is sustained over long periods of time. Most reports of serious starvation experiments (e.g., Roy Walford’s Biosphere 2 experiment) suggest the surfacing of mental disorders and even some cases of psychosis.

Emily Deans has a nice post () on starvation and mental health.

But you may ask: What if my low T problem is caused by aging; you just said that older males tend to have lower T? To which I would reply: Isn’t possible that the lower T levels normally associated with aging are in many cases a byproduct of higher stress hormone levels? Take a look at the figure below, from a study of age-related cortisol secretion by Zhao and colleagues ().



As you can see in the figure, cortisol levels tend to go up with age. And, interestingly, the range of variation seems very close to that in the earlier figure in this post, although I may be making a mistake in the conversion from nmol/l to ηg/ml. As cortisol levels go up, T levels should go down in response. There are outliers. Note the male outlier at the middle-bottom part, in his early seventies. He is represented by a filled circle, which refers to a disease-free male.

Dr. Arthur De Vany claims to have high T levels in his 70s. It is possible that he is like that outlier. If you check out De Vany’s writings, you’ll see his emphasis on leading a peaceful, stress-free, life (). If money, status, material things, health issues etc. are very important for you when you are young (most of us, a trend that seems to be increasing), chances are they are going to be a major source of stress as you age.

Think about individual property accumulation, as it is practiced in modern urban environments, and how unnatural and potentially stressful it is. Many people subconsciously view their property (e.g., a nice car, a bunch of shares in a publicly-traded company) as their extended phenotype. If that property is damaged or loses value, the subconscious mental state evoked is somewhat like that in response to a piece of their body being removed. This is potentially very stressful; a stress source that doesn’t go away easily. What we have here is very different from the types of stress that our Paleolithic ancestors faced.

So, what will happen if you take testosterone supplementation to solve your low T problem? If your problem is due to high levels of cortisol and other stress hormones (including some yet to be discovered), induced by stress, and your low T treatment is long-term, your body will adapt in a compensatory way. It will “sense” that T is now high, together with high levels of stress.

Whatever form long-term compensatory adaptation may take in this scenario, somehow the combination of high T and high stress doesn’t conjure up a very nice image. What comes to mind is a borderline insane person, possibly with good body composition, and with a lot of self-confidence – someone like the protagonist of the film American Psycho.

Again, will the high T levels, obtained through supplementation, suppress cortisol? It doesn’t seem to work that way, at least not in the long term. In fact, stress hormones seem to affect other hormones a lot more than other hormones affect them. The reason is probably that stress responses were very important in our evolutionary past, which would make any mechanism that could override them nonadaptive.

Today, stress hormones, while necessary for a number of metabolic processes (e.g., in intense exercise), often work against us. For example, serious conflict in our modern world is often solved via extensive writing (through legal avenues). Violence is regulated and/or institutionalized – e.g., military, law enforcement, some combat sports. Without these, society would break down, and many of us would join the afterlife sooner and more violently than we would like (see Pinker’s take on this topic: ).

Sir, the solution to your low T problem may actually be found elsewhere, namely in stress reduction. But careful, you run the risk of becoming a nice guy.

Mushroom & Onion Sliders with Aioli Sauce

Every couple of weeks, I crave a juicy burger.  Usually, if ordering one at a restaurant, I can only get through about half, because it's so much food with the bun.  Sometimes I order the burger without the fun, and just eat it with a fork.  Do you do that too?

The other night, I made a sliders (just smaller burgers) and topped them with sautéed onions and mushrooms with a bit of aioli sauce.  We ate it with a side of spinach too.

Sliders

To make the sliders, I used about one pound of lean grass fed beef and portioned them into 5 patties.  I seasoned them with a little low sodium soy sauce and cooked them in a grill pan on medium high for about 4-5 minutes per side until medium.  

Onions & Mushrooms

I cut the onions and mushrooms into small dice and chopped a few cloves of garlic.  Sautee the whole thing in a couple tablespoons of olive oil and season with salt and pepper.

Spinach 

I used a giant bag of spinach and sautéed it in a pot with a little olive oil, salt and pepper, and garlic.  The spinach wilts down so don't be worried it seeming like too much. 

Aioli 

I made aioli by just combining low-fat mayo with dijon mustard and garlic.  Since it was just for two people, I added about 1/8 cup each of the mayo and mustard and one garlic clove.  You typically add a little lemon juice, but I didn't have any.  

*I always use a very light hand when seasoning with salt.  I think it's better to salt your food at the table because you end up using less and tasting it more. 

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Food Reward Friday

This week, Food Reward Friday is going to be a little bit different.  I've received a few e-mails from people who would like to see me write about some of the less obvious examples of food reward-- foods that are less extreme, but much more common, and that nevertheless promote overeating.  Let's face it, even though they're funny and they (sometimes) illustrate the principle, most people reading this blog don't eat banana splits very often, much less pizzas made out of hot dogs.

So this week's "winner" is something many of you have in your houses right now, and which was also the subject of an interesting recent study... potato chips!

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Greek Yogurt Panna Cotta

Hi there, Honey We’re Healthy readers!  I’m back with a little something I haven’t done before here on Megan’s blog - dessert!  

I’m a big believer in moderation when it comes to food and usually indulge in desserts on the weekends.  This luscious panna cotta manages to be both an indulgence and a healthy choice - does it get much better than that??

My husband compared the taste to an orange creamsicle and as soon as he said it, I said, “Yes!  That’s exactly what it tastes like!”  But a more sophisticated creamsicle.  A creamsicle for refined adults, darling.

Traditional panna cotta is made with heavy cream while this lighter version uses 2% milk and Greek yogurt.  The orange zest adds the perfect little punch of flavor and the threads of orange mingled with vanilla bean specks is really quite pretty.  I loved it topped with kiwi slices, blackberries, and raspberries for some added color and a nice dose of antioxidant goodness.

And just a quick note - this recipe is not hard to prepare but it does have to sit in the fridge for a good 8 hours to set.  So be sure to think ahead if you plan to make it!

Greek Yogurt Panna Cotta

Ingredients

1 1-oz. package unflavored gelatin

1 1/2 c. 2% milk

1 tbsp. vanilla bean paste*

1/2 c. sugar

finely grated zest of one orange (I used a microplane to zest a blood orange)

2 c. plain 2% Greek yogurt

grapeseed oil

berries for topping

Pour 1/2 c. milk into a small bowl and sprinkle gelatin over the top to soften.  Let sit without stirring for about 10 minutes.

Meanwhile, pour the remaining 1 c. of milk into a small saucepan over medium heat.  Add vanilla bean paste, 1/2 c. sugar, and orange zest and stir until the sugar dissolves and the mixture starts to simmer.  Remove from the heat and add the gelatin mixture.  Whisk to fully dissolve gelatin.  Transfer to a large bowl and set aside about 10 minutes to cool, then whisk yogurt into mixture until smooth.

Drizzle a bit of grapeseed oil into each of six ramekins and spread on bottom and sides with fingers or a napkin.  Evenly divide yogurt mixture among the ramekins.  Cover and refrigerate until set, 8 hours or up to 2 days ahead of time.

When ready to serve, run a butter knife along the edge of the panna cotta, all the way around the inside of the ramekin.  Invert it onto a plate and give it a good shake or smack on top of a padded surface (I used an oven mitt!) and remove the ramekin.  Top with berries and serve.

*Vanilla extract can be substituted for the vanilla bean paste but you will lose the lovely little vanilla bean flecks in the panna cotta.  You can also substitute a whole vanilla bean - cut in half, scrape the seeds out, and add the seeds and pod to the milk mixture on the stove.  Remove the pod before whisking in the yogurt.

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Thank you for this post from contributing writer, Jennifer, of The Chronicles of Home.  You'll definitely want to check out her blog for more amazing recipes, beautiful home decor, and easy-to-follw DIY projects!

Body Fatness and Cardiovascular Risk Factors

I recently revisited a really cool paper published in the Lancet in 2009 on body fatness, biomarkers, health, and mortality (1). It's a meta-analysis that compiled body mass index (BMI) data from nearly 900,000 individual people, and related it to circulating lipids and various health outcomes.  This is one of the most authoritative papers on the subject.

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Grilled Shrimp Tacos

Last night's dinner was really good and so easy to throw together.  When you need a fast meal, I like to take advantage of grocery store items that help save time.  If you have a bag of frozen shrimp, shredded lettuce (or cabbage), pico, and tortillas, you've basically got shrimp tacos!

Frozen, tail off, peeled and deveined shrimp are always on sale and in our freezer because all you have to do is thaw and heat.  You can thaw them in the fridge, but I usually put them in a strainer and run cold water over them for a couple minutes, then dry with a kitchen towel. 

The store bought pico is super convenient, but I sometimes add a fresh squeeze of lime or more onion since ours tends to be heavy on the tomato.

I made a simple taco sauce with low fat sour cream, a touch of milk, some paprika, salt-free seasoning, and low sodium old bay.  

I grilled the shrimp in olive oil and garlic and seasoned with old bay.  The tortillas were heated in a dry skillet.

Finally, just assemble your tacos.  I layered the sauce, lettuce, pico, sliced avocado, and then the shrimp.

The bag of shrimp above made four tacos. 

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Quinoa Caprese Salad

Happy Monday everyone!  Hope you all had a great, refreshing weekend!  I've been utilizing the chalk wall in our kitchen to write out our weekly meal plan and I love it!  I think I resisted because it's hard to know on a certain day what you're going to want to eat, but I figure, get it all planned out and grocery shopped so you have something to eat and you can just switch the days around if you want.

Preparing weekend lunches is a favorite of mine.  It's really nice to enjoy a home-made meal if you're at the house to eat it:)  With all the weekend running around, sometimes eating while out is more convenient.  This Saturday, having completed the morning errands and getting home in time for lunch, I made a quinoa caprese salad with grilled chicken.  This is one of those easy-to-assemble meals that is packed with protein and flavor.

I start by grilling boneless, skinless chicken breasts in olive oil for a few minutes at the same time I boil the quinoa.  Quinoa cooks quickly, about 8 minutes.  I used 1 cup of quinoa and 2 cups of organic chicken broth to give it more flavor. 

Then, because the caprese ingredients are a favorite combo (tomato, basil, and mozzarella) I assembled them all together. 

Quinoa is a good source of fiber, magnesium, iron, calcium and fiber.  It has a slightly nutty flavor, but mainly takes on the flavors you cook it with.  It cooks quickly, in about 8 minutes.   Then I chopped the cherry tomatoes and mozzarella balls in half and tossed in the basil. 

I seasoned my salad with olive oil, balsamic vinegar, and salt-free seasoning. 

A bright, refreshing (and filling) salad!

After lunch, I portioned the rest out into plastic containers for quick meals later on during the week.  

Have you tried quinoa- do you like it? 

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I finally completed all 12 weeks of the Live Fit challenge (yay!)  and will be bringing you the low down with my progress later this week- I need to get my body fat measured first:) 

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Food Reward Friday

This week's "winner"... the Banana Split!

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The War of the End of the World: The health puzzle posed by its survivors

The War of Canudos took place in Brazil in 1896 and 1897. Canudos was a settlement of several thousand deeply religious Christians, led by a man known as Antonio Conselheiro. They opposed the recent establishment of the Republic of Brazil, particularly the institution of income taxes and civil marriage; the former was considered government-sponsored theft and the latter a sacrilege. The republic had been declared in 1889 following a military coup that deposed Dom Pedro II, an emperor beloved by the common people and under whose rule slavery had recently been abolished.

Canudos was located in the Brazilian sertão, an inhospitable semi-arid region in the northeastern part of the country. The inhabitants of Canudos were the sertanejos. The term jagunço was used to refer to the males, especially the outlaws. Many of the sertanejos lived in semi-starvation, in poor sanitary conditions, and with very limited (if any) access to healthcare. Infant mortality was very high at the time. Those who reached adulthood were typically of small stature, and very thin; not lean, thin – often described as “skin and bones”.

Below is what a typical young jagunço would look like at the time of the War of Canudos. (Some authors differentiate between jagunços and cangaceiros based on small differences in cultural and dress traditions; e.g., the hat in the photo is typical of cangaceiros.) The jagunços tended to be the best fed among the sertanejos. They were also known as cold-blooded killers. The photo is a cropped version of the original one; the grizzly original is at the top of a recent blog post by Juan Pablo Dabove (). The blog post discusses Vargas Llosa’s historical fiction book based on the War of Canudos, the masterpiece titled “The War of the End of the World” ().

Jorge Mario Pedro Vargas Llosa, a Peruvian-Spanish writer and politician, was the recipient of the 2010 Nobel Prize in Literature; “The War of the End of the World” is considered one of his greatest literary achievements. Euclides da Cunha wrote the most famous non-fictional account on the War of Canudos, another masterpiece that has been called “Brazil’s greatest book”, titled “Rebellion in the Backlands” (). The Portughese title is “Os Sertões”. Vargas Llosa’s book is based on da Cunha’s.

Sergio Rezende’s movie, “Guerra de Canudos” (), is a superb dramatization of the War of Canudos. I watched this movie after reading Vargas Llosa’s and da Cunha’s books, and was struck by two things: (a) the outstanding performances, especially by José Wilker, Cláudia Abreu, Marieta Severo, and Paulo Betti; and (b) the striking resemblance of the latter (Betti) to Royce Gracie (), a very nice man whom I interviewed () for my book on compensatory adaptation (), and who is no stranger to Ultimate Fighting Championship and mixed martial arts fans ().

In a nutshell, the War of Canudos went more or less like this. There were four military campaigns against the settlement. The third was a major one, led by one of Brazil’s most accomplished military leaders at the time, Colonel Antônio Moreira César. The jagunços, resorting to guerrilla warfare, fought off the government troops in the first three. The fourth, led by General Arthur Oscar de Andrade Guimarães, saw the jagunços defeated in a war of attrition primarily due to lack of access to food and water, after heavy losses among government troops. At the end, nearly all of the surviving jagunços were executed, by knife – to their absolute horror, and the perverse pleasure of the executioners bent on revenge, as the victims believed that they would not go to heaven if their lives were ended by knife, even against their will.

Ned, what is your point regarding health!?

After going through numerous sources, paper-based and online, academic and non-academic, I am convinced that a significant number of the survivors of the Canudos War lived to their 90s and beyond. This conclusion is based chiefly on comparisons of various dates, especially of interviews with survivors. No single source dedicated to this particular health-related aspect of the War of Canudos seems to exist. There is a video clip that shows some of the survivors (), speaking in Portuguese, with their ages shown in subtitles (“years”, in Portuguese, is “anos”). One of them, a man, is listed as being a supercentenarian.

In modern USA those who live to the age of 90 and beyond are outliers. Less than 2 percent of the population reach the age of 90 (). Most of them are women. My impression is that among the survivors of the War of Canudos, the 90+ percentage was at least 5 times higher; even with access to sanitation and healthcare in modern USA being much better at any age.

If my impression is correct, how can it be explained?

I think that some of the readers of this blog will be tempted to explain the high longevity based on calorie restriction. But the empirical evidence suggests that poor nutrition, in terms of micronutrients and macronutrients, is associated with increased mortality, not the other way around (, , ). Mortality due to poor nutrition is frequently from infectious diseases, in the young and the old. Degenerative diseases are widespread among the overnourished, not the well nourished, and kill mostly at later ages. It is not uncommon for infectious diseases to “mask” as degenerative diseases – e.g., viral diabetes ().

Often people point at hunter-gatherer populations and argue that they are healthy because of their low calorie intake. But mortality from infectious diseases among hunter-gatherers is very high, particularly in children. Others point to the absence of industrial foods engineered for overconsumption, which I think is definitely a factor in terms of degenerative diseases. Some say that a main factor is retention of lean body mass as one ages, referring mostly to muscle tissue, a hypothesis to which the case of the sertanejos poses a problem – what lean body mass!? And, on top of all of their problems, the sertanejos regularly faced long droughts, which may be why they typically had a “dry” look.

Yet others point to low stress. It is reasonable to think that stress is a mediating factor in the development of many modern diseases. Still, the sertanejos living in Canudos have had to endure quite a lot of stress, before and after the War of Canudos. In fact, the depictions of their lives at around the time of the War of Canudos suggest very stressful, miserable lives, prior to the conflict; which in part explains the early success of a religious settlement where life was marginally better.

By the way, the traditional Okinawans have also endured plenty of stress (), and they have had the highest longevity rates in recorded history. Food scarcity has frequently been combined with stress in their case, as with many other long-living groups. Causality is complex here, probably changing direction in different subsets of the data, but I have long suspected that the combination of stress and overnourishment is a particular unnatural one, to which humans are badly maladapted.

A main factor is almost always forgotten: the effective immune systems of those who have been subjected to starvation, poor sanitation, lack of healthcare, and other challenges – especially in childhood – and survived to adulthood. And here some counterintuitive things can happen. For example, someone may be very sickly early in life and barely survive childhood, and then become very resistant to infectious diseases later, thus appearing to be very healthy, to the surprise of relatives and friends who remember “that sickly child”. Immunocompetence is something that the body builds up in response to exposure.

As they say in northeastern Brazil, in characteristic drawl: “Ol’ sihtaneju ain’t die easy”.

Food Reward Friday

This week's lucky "winner"... an unnamed hot dog-laden Pizza Hut monstrosity with tempura shrimp and mayonnaise!

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My Live Fit (Weeks 10 & 11) Recap

Hi all!  Just popping in to share my Week 10 and 11 workout sheets with you.  I'm so happy to be on Week 12 (the final week) now!  I must admit my eating hasn't been that great the last couple of weeks, and I need to improve that.  My schedule is so up and down during the day that I haven't been eating my consistent meals.  I need to figure out how to get that under control- I know I'll feel so much better!

Hope you're having a great week!